The whole idea of "confusing" muscles is insanely simplistic. Muscles don't think and they're not "fooled." That said, varying rep ranges (intelligently) offers benefits. The muscles that define muscle are not all of the same. I'm sure that you've heard of Type I and Type II muscles, right? Some of them are better at
explosive power, while others do better handling endurance tasks. Training endurance-type fibers using higher reps makes sense. The big question is, how do you do mesh the two types of training?