4-hydroxyisoleucine
Fenugreek (Trigonella foenum-graecum) has a long history of use throughout Asia and the Middle East for soothing stomach ulcers, promoting lactation and healing various skin conditions. Recently, researchers found that a free amino acid—4-hydroxyisoleucine—present in minute amounts of the common household spice, may play a role in
weight loss.
Although 4-hydroxyisoleucine was discovered more than a decade ago, only recently have there been manufacturing methods to extract the amino acid on a commercial scale. Expect to see this ingredient making its way to market in various diet formulas soon.
In several studies, researchers have shown that 4-hydroxyisoleucine plays a valuable role in insulin promotion and glucose regulation, which may help to reduce body fat. The amino acid 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which
blood glucose is elevated. Elevated blood glucose after meals leads to increased body fat production.
More significantly, the effect of 4-hydroxyisoleucine appears to be glucose dependent, meaning the higher the blood glucose level, the greater the insulin-promoting response elicited by 4-hydroxyisoleucine. By helping to regulate insulin needs, 4-hydroxyisoleucine works as an adaptogen.
In addition to being useful for weight loss, 4-hydroxyisoleucine's insulin-promoting effects may be beneficial to non-insulin-dependent diabetics because standardized 4-hydroxyisoleucine extracts can help to maintain a stable glucose level (Diabetes, 1998).
Soluble fiber in whole fenugreek may also aid in weight loss. These fibers, most notably galactomannans, have been shown to sequester fat. They appear to bind directly to dietary fat and reduce its absorption into the body.
Alot of the newer creatines have this in it to increase creatine uptake,I found the fenugreek seed here dirt cheap
http://www.doctorstrust.com/search.h...C%20Fenugreek; just dont know what kinda dosage you would take of these to get the 4-hydroxyisoleucine benefits.I have seen straight up 4-hydroxyisoleucine here
http://www.bulknutrition.com/?products_id=1583 Sounds expensive to me but I have no clue what the doses are.