Glucosamine
SUMMARY OF SCIENTIFIC EVIDENCE:
- 1. CUTANEOUS AGING: Oral glucosamine with a mixture of antioxidants decreased the number of wrinkles in a small trial.
- 2. OSTEOARTHRITIS: Multiple short-term studies have demonstrated reductions in pain scores and radiographic improvement for patients with osteoarthritis supplemented with glucosamine.
- 3. PAIN, KNEE: A small trial of patients with unspecified knee pain demonstrated reduction in pain but minimal improvement in clinical and functional tests.
- 4. TEMPOROMANDIBULAR JOINT DISORDER: A combination glucosamine and chondroitin supplement decreased the sounds associated with temporomandibular joint disorder (TMJ) and a reduction of over-the- counter medication required for pain relief.
Chondroitin
cataract extraction
corneal preservation for transplantation
coronary
heart disease (inconclusive)
dry eyes (effective)
interstitial cystitis (possibly effective)
osteoarthritis (effective)
snoring (inconclusive)
temporomandibular joint disorder (possibly effective)
MSM
MSM's efficacy appears to rest primarily on its
analgesic and anti-inflammatory properties. Muscle spasm, improved
blood flow, and a reduction in scar tissue formation appear to be enhanced with MSM
Drs. SW Jacob and RM Lawrence have each conducted controlled clinical studies of
MSM treatment for arthritis patients. Dr. Jacob's study involved 12 patients and compared
Motrin (R), a nonsteroidal anti- inflammatory drug, to MSM. Patients were randomly assigned to take 600 milligrams of Motrin (R) or 6 grams of MSM daily. After one month subjects in both groups reported similar pain relief. Sixteen patients with arthritis in Dr. Lawrence's double-blind study were assigned a placebo or MSM
750 milligrams three times daily. Pain relief was more effective with MSM than placebo. Drs. Jacob and Lawrence also report case examples of patient-reported relief for non-migraine headache, tendinitis, carpal tunnel syndrome, fibromyalgia, asthma, sinusitis, pollen allergies, lupus erythematosus, interstitial cystitis, and scleroderma.