Good Article Concerning The Dangers of No2

[bimmerkidd]

Hey, after becoming somewhat interested in taking No2 I came across this great article, which explains some of the risks involved. I visited a few other bodybuilding forums and after talking to some people who have taken it, I no longer think that No2 is worth the money or the dangers to my body. Anyway, I just thought I'd share...sorry if you guys have already seen this article.



The study focuses on nitric oxcide synthesis and its effect on vasodilatation. At first it seems that science backs NO2, but upon further inspection you will see that NO2 is actually quite dangerous.

The study:

Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.

Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ, Webb DJ.

Department of Nephrology and Hypertension, University Hospital Utrecht, The Netherlands. t.rabelink@digd.azu.nl

BACKGROUND: The role of endothelin (ET)-1 in maintenance of basal vascular tone has been demonstrated by local and systemic vasodilatation to endothelin receptor antagonists in humans. Although the constrictor effects mediated by the vascular smooth muscle ET(A) receptors are clear, the contribution from endothelial and vascular smooth muscle ET(B) receptors remains to be defined. The present study, in human forearm resistance vessels in vivo, was designed to further investigate the physiological function of ET(A) and ET(B) receptor subtypes in human blood vessels and determine the mechanism underlying the vasodilatation to the ET(A)-selective receptor antagonist BQ-123. METHODS AND RESULTS: Two studies were performed, each in groups of eight healthy subjects. Brachial artery infusion of BQ-123 caused significant forearm vasodilatation in both studies. This vasodilatation was reduced by 95% (P=.006) with inhibition of the endogenous generation of nitric oxide and by 38% (P<.001) with coinfusion of the ET(B) receptor antagonist BQ-788. In contrast, inhibition of prostanoid generation did not affect the response to BQ-123. Infusion of BQ-788 alone produced a 20% reduction in forearm blood flow (P<.001). CONCLUSIONS: Selective ET(A) receptor antagonism causes vasodilatation of human forearm resistance vessels in vivo. This response appears to result in major part from an increase in nitric oxide generation. ET(B) receptor antagonism either alone or on a background of ET(A) antagonism causes local vasoconstriction, indicating that ET(B) receptors in blood vessels respond to ET-1 predominantly by causing vasodilatation.


PubMed


Here lies the problem; vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, sudden drop. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to catastrophe!

Keep this in mind the next time you consider using any supplement that claims prolonged pump due to nitric oxide synthesis.

[DaLinkWent]

Thanks for the article but I think it's a tad off base. I have no idea what ingrediat they are talking about but the only thing that's in NO2 is arginine.

Here lies the problem; vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, sudden drop. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to catastrophe!

Anybody with serious blood pressure issues are URGED NOT to take NO2 or any supplement really unless instructed by their doctor.

I would love to hear some input from guys who post articles like Steve and IronMan to hear what they have to say!

[bimmerkidd]

Yeah, I think some more input would be great as well. As far as the ingredients....I wouldn't stress the safety of what goes into a suppliment as much as its effects on the body. No2 is known to increase Nitric Oxide Synthesis, which is what causes the so called "perpetual pump." When your veins are stretched for long periods of time, your blood pressure drops, which could lead to some major long term problems. In my personal opinion, $60.00 for one bottle is not worth the extra pump or the risk to my body. Just my .02 though.

[TheBigness]

Originally Posted by bimmerkidd

Yeah, I think some more input would be great as well. As far as the ingredients....I wouldn't stress the safety of what goes into a suppliment as much as its effects on the body. No2 is known to increase Nitric Oxide Synthesis, which is what causes the so called "perpetual pump." When your veins are stretched for long periods of time, your blood pressure drops, which could lead to some major long term problems. In my personal opinion, $60.00 for one bottle is not worth the extra pump or the risk to my body. Just my .02 though.

lol well then dont take it. for most people NO2 is a very safe, self-improving, ego-inflating waste of hard earned money

[DaLinkWent]

lol well then dont take it. for most people NO2 is a very safe, self-improving, ego-inflating waste of hard earned money

LOL
This is the best description of NO2 I have ever heard! Talk about hitting the nail on the head. Nice analogy

[Fitness4U]

bimmerkidd,

No2 is based on an Amino Acid, Arginine. You should have no problems.
When taking No2 you want to have enough carbohydrates in you daily food intake. Not when
you are going on a low carb diet.

[BBnow]

ur reasearch is false

[casanova88]

first - and i dont mean to sound rude - but how much of this article do most of you even fully understand

i am not questioning anyones intelligence, but this was written for medical professionals, not the general public, and that makes a difference in who should be critiqueing it.

second, they seem to be drawing an extreme conclusion off of data that does not support their conclusion

this is like trying to tell ppl their eyes really will pop out of their head if they hold their nose when they sneeze. yes there might be marginally more pressure, but nothings going to go boom, pop out or fall off

NO2 will dilate a vein, but not make it the size of a PVC pipe - lets be realistic - and recognize this article has aboslutely no specifications - just vague and daunting generalizations

arginine's vasodilation brings blood to damaged areas. this increases recovery. doctors have at times (recent, modern times) used small doses of electricity on patients w/ injuries to localize blood to help with the healing process. not the same but a similar concept, and while doctors dont generally know squat about nutrition, they do about injuries

long story short - i think is is totally exaggerated and unsubstantiated

i wouldnt worry

[Lee J B]

Holy crap casanova88 bro, where the HELL have you been bro !? Glad to see you around again....

[casanova88]

hey Lee whats up man! sorry i've been gone so long again

this time my excuse is computer trouble. i've been trouble shooting forever. i thought it was a CMOS battery , tried it and it didnt help. i'm going to have to take my computer in to be serviced.

basically i've been computerless for 9 weeks now

i get on at a public library computer when i can - its all i can do right now- but it is cool to be missed lol

well i'll get on when i can but it might be a bit before i'm on regularly

[Lee J B]

Cool bro, good to know your still hanging around Hope the computer is fixed soon, good luck!

[Merrida]

Well given the fact that whether you're talking about personal training or bodybuilding supplements, -- you're talking about two unregulated fields, and that makes it difficult to find information that is not at least biased in some direction, -- either by subjective belief and preference, or by financial backing for "clinical studies."

Most "reports" tend to rely on anecdotal evidence, which has for some reason, far more impact on sales.

Clinical trials can "mean" a lot of different things, - they do not infer medical approval or backing.

OTC meds, RX meds, vitamins and supplements, and exercise,...they all will tell you to seek medical supervision, and most will also state up-front the potential risks associated ... all it takes is one person to experience something and it goes on the books.

[shades6234]

well not that this has anything to do with it but I felt great when I went through a bottle of No2. Can't say it improved my strenght but I was pumped and I seemed to digest better.

[bimmerkidd]

Good post casanova88, I agree with a lot of what you said. The article that I posted was actually taken from www.abcbodybuilding.com. I was considering taking No2 for a while but after asking a few of the Moderators over there it sounded like a mildly hazardous waste of money. I have a friend that I lift with who started No2 a few weeks back and he has been very disappointed. He works at GNC and after reading that $2 book that they have there about No2 he thought that it would work wonders for him. I was talking to him yesterday and he told me that he isn't even going to finish off his $60.00+ bottle.....even asked me if I wanted the rest of it. (I declined) I have heard similar stories from a few of my other workout buddies. No2 may or may not be entirely safe but why even take it if its not going to make you stronger or even sustain any of the pumps after you cycle off??? $60.00/month is a lot to pay for a better feeling pump. IMO at least....

[goose16]

has any one tried like a buffered creatine like vaso2