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Old 09-Oct-03, 06:40 PM   #1
Lee J B
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Got High cholesterol ? On Cycle ? Read...


When on cycle, your cholesterol levels tend to rise dramatically to > 200, your HDL drops to about 10-20, and your LDL increases to 150-200.

Well, there's one supplement out there that can remedy that.
Its one of the things I have been researching for the past 4 months. I posted this at AF already, but I'll post it here as well.

Its called policosanol. Its not expensive at all, and works better than any prescription cholesterol lowering drug with no side effects whatsoever.

This is just a brief description:

Policosanol is a natural supplement derived from sugar cane. The main ingredient is octacosanol. Octacosanol is an alcohol found in the waxy film that plants have over their leaves and fruit. The leaves and rinds of citrus fruits contain octacosanol, and so does wheat germ oil.

[Very important section]

Policosanol has been shown to normalize cholesterol as well or better than cholesterol-lowering drugs, without side effects such as liver dysfunction and muscle atrophy.1 Efficacy and safety have been proven in numerous clinical trials, and it has been used by millions of people in other countries. Policosanol lowers harmful LDL-cholesterol and raises protective HDL-cholesterol. HDL-cholesterol removes plaque from arterial walls.

Policosanol helps stop the formation of artery lesions too, an effect similar to that of statin drugs. This was proven in studies on rabbits fed a diet designed to create high cholesterol. According to researchers “in most policosanol-treated animals, atherosclerotic lesions were not present, and in others, thickness of fatty streaks had less foam cell layers than in controls.,3

Policosanol also inhibits the oxidation of dangerous LDL-cholesterol4 which promotes the destruction of blood vessels by creating a chronic inflammatory response. Oxidized LDL can also provoke metalloproteinase enzymes.5 These enzymes promote blood vessel destruction, partly by interfering with HDL’s protective effect. Studies show that rats treated with policosanol have fewer foam cells, reflecting less inflammatory response causing less blood vessel destruction.6,7

Healthy arteries are lined with a smooth layer of cells so that blood can race through with no resistance. One of the features of diseased arteries is that this layer becomes thick and overgrown with cells. As the artery narrows, blood flow slows down or is blocked completely. Policosanol can stop the proliferation of these cells in much the same was as lipid-lowering drugs.8,9

Policosanol also inhibits the formation of clots, and may work synergistically with aspirin in this respect. In a comparison of aspirin and policosanol, aspirin was better at reducing one type of platelet aggregation (clumping together of blood cells). But policosanol was better at inhibiting another type. Together, policosanol and aspirin worked better than either alone.10,11

Thromboxane is a blood vessel-constricting agent that contributes to abnormal platelet aggregation that can cause a heart attack or stroke. Significant reductions in the level of thromboxane occur in humans after two weeks of policosanol.12

People with elevated LDL-cholesterol (over 100) or low HDL-cholesterol (under 50) should seek to protect themselves from the potentially fatal effects of cardiovascular disease. Some people can achieve optimal cholesterol levels via dietary modification, while others require intervention with dietary supplements like policosanol or prescription drugs.

Some people will not achieve adequate results with policosanol or FDA-approved cholesterol-lowering drugs. That is why it is so important to have your blood tested when using policosanol (or FDA-approved drugs). Some people will only require 5 mg to 10 mg a day of policosanol, while others may need 20 mg/day. The same dosage variation may be true of cholesterol-lowering drugs.

A standard blood chemistry profile measures total cholesterol, LDL-cholesterol, HDL-cholesterol and numerous other parameters such as liver and kidney function. By taking this blood test two months after beginning policosanol, you can adjust the dose to meet your individual need. This standard blood chemistry test can be done at your doctor's office or you can order it directly by going here.



Ok....so thats the concise version of what policosanol does...but then you need proof that it works. Thats where experimentation comes in...i.e. Real life blood tests using policosanol while on AAS.

Results (Test subject will remain nameless but this is a real lab test):

May 21st, 2003(On Fina and test)

Total Cholesterol: 236
HDL: 10
LDL: 199

40mg/day Of policosanol

Aug.12th, 2003(Still on Fina and test + masteron)

Total Cholesterol: 134
HDL:19
LDL: 96


Changes over the 2-month period:


Total Chol Change: 236-134 = 102/236 = 43% reduction
HDL Change:10-19 = 9/10 = 90% increase
LDL Change:199-96 = 103/199 = 51.76% reduction


Just to stress again, if your not on cycle and you have naturally high cholesterol, this is absoloutly much better than anything you can buy and ANYTHING that can currently be prescribed to you - and it has zero side effects.

Keep Flyin & Enjoy !

Lee
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Old 24-Mar-06, 07:49 AM   #2
tjcny
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Poloicosanol


Thanks for the information. Could you tell me how long it takes for it to kick in? The resason I ask is because I recently went off Crestor and started policosanol and about a week after had a medical exam which included a cholesteral exam. My cholesteral went from 176 while on Crestor to 202 after about a week on policosanol. The only explination I can give is that the poli takes awhile to build up in effectiveness in the system. Otherwise, maybe it just doesn't work.

What's your experience been?
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Old 24-Mar-06, 06:07 PM   #3
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mm i think you will find that post was written nearly 3 years ago and that user does not post here any more.
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Old 24-Mar-06, 06:11 PM   #4
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ill post some info on it when i find it in the mean time i find
garlic
fishoils
co enzyme q10

great for the CV system and cholesterol.
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Old 28-Mar-06, 12:53 PM   #5
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LIPID METABOLISM EFFECTS:
  • a. The cholesterol reducing effects of policosanol may be due to stimulation of the receptor-mediated degradation of low density lipoprotein, similar to that of HMG CoA reductase inhibitors (Arruzazabala et al, 1994).
  • b. The effect of octacosanol on increasing strength and endurance may be caused by lipid metabolism and the conversion of lipids to energy. Free fatty acids and triglycerides increase muscle energy needed for contraction. C-octacosanol levels were significantly increased in the muscle of octacosanol-fed animals exposed to exercise, suggesting storage for use during exercise. Octacosanol may play a role in the mobilization of stored lipids in the form of free fatty acids from fat cells for energy in muscles, possibly through hormonal-like mechanisms (Kabir & Kimura, 1994).
  • c. C-acetate incorporation of total cholesterol was dose- dependently prevented following 48-hour incubation of policosanol with human lung fibroblasts. This effect was absent when labeled mevalonic acid was used as a precursor, suggesting that policosanol affects the cholesterol biosynthesis pathway at the first step prior to the generation of mevalonic acid. Policosanol may act at the level of low-density lipoprotein (LDL) receptor binding as LDL binding, absorption, and degradation was increased, even at low doses, when cholesterol synthesis was not inhibited. HMG CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase enzyme inhibition may also be a feasible mechanism for reduced cholesterol synthesis. Increased LDL activity may occur due to reduced cholesterol synthesis (Menendez et al, 1994).


HYPERLIPIDEMIA, capsule: 5 milligrams (mg) policosanol twice daily (Stusser et al, 1998; Castano et al, 1996; Canetti et al, 1995; Castano et al, 1995; Torres et al, 1995). The most commonly studied dose is 5 mg twice daily but doses as low as 2 mg daily have caused hypocholesterolemic effects (Batista et al, 1996). Doses of 10 mg twice daily have also been used.
  • a. Policosanol 5 mg twice daily and policosanol 5 mg plus aspirin 125 mg daily improved hyperlipidemic profiles in patients with ischemic heart disease (mean age=48) in a randomized, placebo-controlled, double-blind study (n=41) (Stusser et al, 1998).
  • b. Policosanol 1 mg twice daily reduced total and low-density lipoprotein (LDL) cholesterol levels by 14.8% and 15.6%, respectively, in patients with hypercholesterolemia and coronary heart disease (CHD) (mean age=53.6) in a randomized, placebo- controlled, single-blind study (n=23) (p less than 0.001 and 0.05, respectively, compared to baseline) (Batista et al, 1996).
  • c. Policosanol 5 mg twice daily significantly reduced total and low-density lipoprotein (LDL) cholesterol levels in type II hypercholesterolemic and hypertensive patients (mean age=57) in a one year randomized, placebo-controlled, double-blind study (n=58) (Castano et al, 1996).
  • d. Total and low-density lipoprotein (LDL) cholesterol levels were significantly reduced and maintained following policosanol 5 mg twice daily in type II hypercholesterolemic patients (mean age=57) in a two-year randomized, placebo-controlled, double-blind study (n=69) (Canetti et al, 1995).
  • e. Policosanol 5 mg twice daily significantly reduced total and low-density lipoprotein (LDL) cholesterol levels in elderly type II hypercholesterolemic patients (mean age=65) in a one-year randomized, placebo-controlled, double-blind study (n=62) (Castano et al, 1995).
  • f. Policosanol reduced total and low-density lipoprotein (LDL) cholesterol levels by 17.5% and 21.8%, respectively, in non- insulin dependent diabetic hypercholesterolemic patients (mean age=57) in a randomized, placebo-controlled, double-blind study (n=29) (p less than 0.01 compared to baseline and placebo) (Torres et al, 1995).
  • g. Policosanol significantly reduced total and low-density lipoprotein (LDL) cholesterol levels in type II hypercholesterolemic patients (mean age=57) in a randomized, placebo-controlled, double-blind study (n=22). Subjects received oral policosanol 5 mg daily or placebo for 2 months. Doses were increased to 10 mg daily for another 2 months and then increased to 20 mg daily for another 2 months. Subjects were instructed to take policosanol at lunch and dinner (Pons et al, 1994).
Studies show it to be very effective and with its mechanism of action i donr believe you will notice much in a week give it the one to 2 months and get retested
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Old 30-Mar-06, 05:02 PM   #6
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Thanks for the info Maxgain.
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Old 30-Mar-06, 06:09 PM   #7
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no probs hope it works if not look into the other supps i mentioned
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