IGF-1
IGF is a naturally occuring substance in the body (made up of a chain of 70 polypeptide chain amino acids), you have your highest levels of IGF at puberty, IGF is the main substance responsible for all growth during those years. Obviously IGF effects vary depending on what tissue it's in, bodybuilders might be interested in the increased protein synthesis (massive increase that is) and increased animo acid absorbtion (sp?). IGF does not allow the insulin to transport glucose etc into or across cell membranes in any tissue, therefore it forces your body to burn fat for energy.
Now it get's interesting though, using this substance will cause the effect known as 'hyperplasia' , which some of you will know is the actual splitting of muscle cells. So why is this good right ? ... Well it's good because when you finish puberty or basically when your growth plates fuse, your left with a set number of muscle cells, you can't actually GAIN more muscle cells you can only increase their size with training, ... even steroid use will only cause hypertrophy to occur and not the hyperplasia. So IGF actually allows you to gain muscle cells to your body's cell count, which as you can imagine leads to unimaginable gains and new muscle density... but guys seriously consider that this drug will seriously alter your genetic capabilities and the effects are irreversible, seriously.
I'm worried about organ and bone enlargement!
Understandably many of you will be reading this and thinking how can ANYONE possibly take these kinds of risks, I mean, who the hell wants to enlarge their intestines and such like right ? Well with HGH this would nearly always be the case with long and high dose's, with IGF it is likely to go where we want it because it can only bind to certain cells, which are all located in muscle tissue. These cells are called myogenic (sp?) cells which I think you can only get in
connective tissue's (cue biologist here
), these cells are responsible for the production of myoblast cells... Now your all thinking about that new supp to do with myoblast right ? ... I've answered a few q's on the board about it can't remember who asked me though, search will bring it up. These myoblast cells repair and build new musclue tissue, nerve cells, ligaments, tendons.... etc, so if the medical world use's it my guess is it will be for this kind of treatment, sports injuries and such like. So IGF is going to be great for strength because of the increased myoblast cell count.
Ok, Why should I choose this over HGH?
Those of you with cash to burn or scripts might be pondering a HGH cycle, well HGH doesn't directly increase muscle cell count, it works by increasing the amount of insulin your body can use effectively, gradually increasing protein synthesis levels and actually stimulates the release of IGF, so HGH is a precursor to IGF. This makes IGF the better choice IMO. Plus with HGH you often need to either use it for a seriously long time, and high enough dose's or you need to stack it with
anabolic steroids, whereas IGF can be used on it's own for a short period of time and gains can be seen and kept relatively easily.
IGF-1 R3
"Insulin-Like Growth Factor Recombinant 3" This is basically a longer lasting substance than the above, but shorter lasting substance than the Long R3, this is in your system around 8 - 10 hours. This is the only way I know of that this substance has been altered, so all of the above and below are applicable to this one too (accept half life times).
Long R3 IGF-1
What is Long R3 IGF-1 ?
IGF "Insulin-like growth factor". Even on our corner of the net here I've seen this drug is getting some major hype.... and understanably so, used correctly it's a breakthrough but used wrongly and it's devastating... life threatening I would go as far as saying. As mentioned above, IGF-1 is a polypeptide chain of 70 amino acids, well the Long R3 version is a chain of 83 AA's and so it has been altered somewhat, which cause it to avoid binding to proteins in the human body and allow it to have a much longer half-life, around 20-30 hours. Because it stops binding to these proteins it's supposed to be a lot more potent because when the protein binds it inhibits the growth capabilities of IGF's.
What Should I know before buying ?
You should know that this is a very powerful drug, it by FAR surpass's (sp?) HGH and you are potentially unlocking your genetic potential. ANY form of IGF is always supplied in a powder form, don't buy any vials or pre-diluted stuff. (If your genuinally interested I can take a pic of some for you, just PM me). DO NOT buy this drug from a company, buy it from a reputable source if possible. You will need to be able to store this stuff in a fridge so make sure the people you live with have been fed a fake story of what this stuff is.
Cycle Info
Before you even read on read this.... IGF in any form has not even been approved for pharmacutical use by the FDA yet, nevermind for use by people with little knowledge of stuff like this that are not being given it under medical supervision, this is another reason why you shouldn't buy from a company unless you know for sure because it hasn't been approved for anything but lab use. Since this is a relatively new drug I haven't heard much in the way of the ultimate cycle length and dose, however I have heard stuff floating around so this is my opinion.....doses can be very low, it's a bit like steroids... dont start high, what's the point ? 20mcg / day can get you very far with this drug, don't go above 120 - 130mcg / day or your going to be getting some very unpleasent side effects mentioned in the next section. Good lengths are 50 - 55 days on and 40 days off, I personally advise as much time off as you had on, but science would argue agaisnt my old school opinions for this drug. Since it's bought in milligrams, you'd need 1mg to sustain a 20mcg cycle for 50 days... which IMO would be an ideal dose for trial of this drug. Note that you can stack IGF with just about any steroid, and this is advised for increased gains and especially good for a high anabolic state post-cycle....avoiding the hard crash from some steroids. Furthermore you might wanna know that IGF does NOT affect testosterone (or Testfree) levels, so your hormones stay in balance.
Side's
Well generally speaking, this drug hasn't had much reported side effects. Although at high dosages your asking for trouble, everything that this drug binds to will grow... just like HGH, thus with long excessive use and high dosages your going to be growing unwanted gut's and enlarging your internal organs.... and you really don't want enlargements of the heart. By high dose's I'm talking 120mcg + ... which is gonna set you back a ton for 50 days anyway even at media grade. Usual's apply for medium dose's though, headaches, nausia & cramps.... there's is one other thing that's been heard for the long version in particular which is that you feel a lot more tired (more than you do on IGF-1) and will need a considerable more amount of sleep.
Gains
From a couple guys I personally know I can tell you that the gains you get you keep post-cycle....however gains are limited, not like steroids... so don't expect massive gains. Tremendous pumps are also reported in the gym, which would mean it almost deffinitly has a cell volumizing effect.
Conclusion
Safety 9/10
Gains 5/10
Post-cycle crash 10/10 (10 being no crash)
Keep Gains 9/10
Just like to say that these are the bare bones and they are from what I already know, so this is not deffinite, if you know something that's not here, add to it ! If you have any more direct questions, ask them in this thread and I'll try my best to answer them for you.
Peace out bro's.
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